Project Portfolio

I. Softwares

rareGWAMA
rareGWMA is a Swiss army knife-like sofeware for imputation based GWAS meta-analysis. It could perform gene-level tests. The latest implementation is for TESLA (optimal linear combination of association statistics), a novel method for trans-ethnic TWAS (transcriptome-wide association studies).

simpleMR
simpleMR is a one-stop R package for performing Mendelian randomization using GWAS summary data. It implementes the most popular MR methods on the market, also provides informative diagnostic plots.

[Udacity projects]

II. Posters & presentations

ASHG 2017
Poster presentation
Topic: Assessing the causal impact of smoking and drinking on human health outcomes: Using 442 novel genetic associations for smoking and drinking addictions and a robust ensemble method for causal inference.

ASHG 2019
Platform talk
Topic: The functional landscape and essential genes discovery in genetic etiology of tobacco use.

ASHG 2020
Award
Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research semifinalist 2020 (news)
Platform talk
Topic: Trans-ethnic Transcriptome-wide Association Study for Smoking Addiction in 1.3 Million Individuals yields insights into the Biology of Tobacco Addiction and Drug Repurposing

III. Publications

2016-present

Jiang Y, Chen S, McGuire D, Chen F, Liu M, Iacono WG, Hewitt JK, Hokanson JE, Krauter K, Laakso M, Li KW, Lutz SM, McGue M, McGuire D, Pandit A, Zajac G, Boehnke M, Abecasis GR, Vrieze SI, Zhan X, Jiang B, Liu DJ. Proper Conditional Analysis in the Presence of Missing Data: Application to Large Scale Meta-analysis of Tobacco Use Phenotypes, PLOS Genetics. 2018, 14 (7), e1007452
Liu M, Jiang Y, Wedow R, Li Y, Brazel D, Chen F, Datta G, et al, Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use, Nature Genetics. 2019, 51, 237–244
Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, …, Chen F, …, Liu DJ, Howson JMM, Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci, Molecular Psychiatry. 2019

2006-2012

Chen F*, Wang C, Li R, An J, Yu L. T-LAK cell-originated protein kinase is essential for the proliferation of hepatocellular carcinoma SMMC-7721 cells. Cell Biochem Funct. DOI: 10.1002/cbf.2964
Cao L, Chen F, Yu L. Evolution of cell cycle control during metazoa emergence: insights from phylogeny analysis of CDK and Cyclin proteins. (Co-first author) Mol Biol Evol. 2014, 14:10
Liu M, Shen S, Chen F, Yu W, Yu L. Linking the septin expression with carcinogenesis. Mol Biol Rep. 2010 Oct;37(7):3601-8.
Yu W, Ding X, Chen F, Liu M, Shen S, Gu X, Yu L. The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation. Mol Cell Biochem. 2009 May;325(1-2):61-7.
Ding X, Yu W, Liu M, Shen SQ, Chen F, Cao L, Wan B, Yu L. GTP binding is required for SEPT12 to form filaments and to interact with SEPT11. Molecules & Cells (Springer Science & Business Media BV) 25 (3)
Li R, Wan B, Zhou J, Wang Y, Luo T, Gu X, Chen F, Yu L. APC/C Cdh1 Targets Brain-Specific Kinase 2 (BRSK2) for Degradation via the Ubiquitin-Proteasome Pathway. PloS one 7 (9), e45932

Institutions and regions distribution of my selected citations (Data Source: Web of Science, April, 2019)

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